Comments on: 1-Deoxynojirimycin and 1-Deoxyaltronojirimycin http://totallysynthetic.com/blog/?p=2178 4,512 Ph. D. students died to make this blog... Mon, 06 Sep 2010 21:36:02 -0600 hourly 1 http://wordpress.org/?v=3.0 By: Tot. Syn. http://totallysynthetic.com/blog/?p=2178&cpage=1#comment-275423 Tot. Syn. Tue, 22 Dec 2009 21:03:40 +0000 http://totallysynthetic.com/blog/?p=2178#comment-275423 Fixed, but it does take *quite* a lot of time to write these posts (about 4-5 hours per post), and I'm a crap proof reader. Ask the chaps that proofed my thesis for me... Fixed, but it does take *quite* a lot of time to write these posts (about 4-5 hours per post), and I’m a crap proof reader. Ask the chaps that proofed my thesis for me…

]]> By: Tot. Syn. http://totallysynthetic.com/blog/?p=2178&cpage=1#comment-275422 Tot. Syn. Tue, 22 Dec 2009 21:02:25 +0000 http://totallysynthetic.com/blog/?p=2178#comment-275422 Fixed... at last! Fixed… at last!

]]> By: - http://totallysynthetic.com/blog/?p=2178&cpage=1#comment-275290 - Sun, 20 Dec 2009 22:07:28 +0000 http://totallysynthetic.com/blog/?p=2178#comment-275290 Come on, Tot. Syn.! We all make mistakes, admittedly I myself make more than others… But you're just going to leave the errors in your title graphic, even after they were pointed out to you in the first comment? You left an error that you yourself acknowledged in the article before this, too. What, are you writing for Angewandte Chemie now? Come on, Tot. Syn.! We all make mistakes, admittedly I myself make more than others… But you’re just going to leave the errors in your title graphic, even after they were pointed out to you in the first comment? You left an error that you yourself acknowledged in the article before this, too.

What, are you writing for Angewandte Chemie now?

]]> By: Gui http://totallysynthetic.com/blog/?p=2178&cpage=1#comment-275288 Gui Sun, 20 Dec 2009 21:54:57 +0000 http://totallysynthetic.com/blog/?p=2178#comment-275288 I see it clearly now. Thank you very much for your comment! I see it clearly now. Thank you very much for your comment!

]]> By: a-non http://totallysynthetic.com/blog/?p=2178&cpage=1#comment-275195 a-non Sat, 19 Dec 2009 23:04:11 +0000 http://totallysynthetic.com/blog/?p=2178#comment-275195 also, as far as the mesylate epoxide selectivity goes, if in the event that the nitrogen attacked the epoxide it would generate an alkoxide, which would bite back down - reforming the epoxide. Making this a non-productive pathway for the reaction. also, as far as the mesylate epoxide selectivity goes, if in the event that the nitrogen attacked the epoxide it would generate an alkoxide, which would bite back down – reforming the epoxide. Making this a non-productive pathway for the reaction.

]]> By: gippgig http://totallysynthetic.com/blog/?p=2178&cpage=1#comment-275096 gippgig Sat, 19 Dec 2009 07:52:14 +0000 http://totallysynthetic.com/blog/?p=2178#comment-275096 The nitrogen attacks the mesylate carbon from below so the methylene in between ends up in front of the newly formed six-membered ring, as shown. Try making a model if you're still confused. The nitrogen attacks the mesylate carbon from below so the methylene in between ends up in front of the newly formed six-membered ring, as shown. Try making a model if you’re still confused.

]]> By: Gui http://totallysynthetic.com/blog/?p=2178&cpage=1#comment-275003 Gui Fri, 18 Dec 2009 14:25:46 +0000 http://totallysynthetic.com/blog/?p=2178#comment-275003 Isn´t the stereochemistry of the resulting aziridinium ion wrong? I mean the amine should attack the mesilate at the opposite face. And shouldn´t it attack the epoxide as well? Just thoughts. :) Isn´t the stereochemistry of the resulting aziridinium ion wrong? I mean the amine should attack the mesilate at the opposite face. And shouldn´t it attack the epoxide as well? Just thoughts. :)

]]> By: Gui http://totallysynthetic.com/blog/?p=2178&cpage=1#comment-275002 Gui Fri, 18 Dec 2009 14:23:10 +0000 http://totallysynthetic.com/blog/?p=2178#comment-275002 You are not the only one. You are not the only one.

]]> By: Pilky01 http://totallysynthetic.com/blog/?p=2178&cpage=1#comment-274987 Pilky01 Fri, 18 Dec 2009 12:01:55 +0000 http://totallysynthetic.com/blog/?p=2178#comment-274987 To OrgLettWorthy, I personally can't think of such an elegant way to get from the starting material in step 1 to the product of step 2 in a diastereoselective manner, in just 2 steps! Plus its a pretty versatile intermediate they have got to, maybe this is why the referees deemed it "Org Lett worthy". I think its a really neat idea, im sure im not the only one. To OrgLettWorthy,

I personally can’t think of such an elegant way to get from the starting material in step 1 to the product of step 2 in a diastereoselective manner, in just 2 steps! Plus its a pretty versatile intermediate they have got to, maybe this is why the referees deemed it “Org Lett worthy”.
I think its a really neat idea, im sure im not the only one.

]]> By: J-ster http://totallysynthetic.com/blog/?p=2178&cpage=1#comment-274840 J-ster Thu, 17 Dec 2009 08:53:40 +0000 http://totallysynthetic.com/blog/?p=2178#comment-274840 I've had this problem repeatedly for some considerable time. It appears that ACS release the article titles and links in their feeds and alerts, before the link works. If you can wait for a day or so, it's usually working by then....an annoyance, though! I’ve had this problem repeatedly for some considerable time. It appears that ACS release the article titles and links in their feeds and alerts, before the link works. If you can wait for a day or so, it’s usually working by then….an annoyance, though!

]]>