Comments on: (iso)Bongkrekic Acid

By: TWYI

TWYI — Tue, 19 Jan 2010 03:32:51 +0000

since when is Singapore in China?

By: claud

claud — Fri, 15 Jan 2010 21:28:25 +0000

One of the largest uses (1000s of tonnes/annum) for methylheptenone is for the manufacture of vitamin A and phytol.

By: aaaa

aaaa — Wed, 13 Jan 2010 12:01:40 +0000

Another comment about the Si-protected oxidations. Not very surprising, I have personally used a simple Swern on primary OTES-protected material and it works just fine – simply longer reaction times, and you get the aldehyde in high yield.

By: aaaa

aaaa — Wed, 13 Jan 2010 11:58:34 +0000

Actually this Stille-Migita coupling using CuTC, Pd, and P-reagent comes from Furstner’s lab.:
A Versatile Protocol for Stille-Migita Cross Coupling Reactions.
Chem. Commun. (Cambridge) 2008, 2873-2875.
And since I was in the group at that time, I know it was developed for the little bastard Amphidinolide H (for the bloody-difficult diene unit).

By: Ian

Ian — Wed, 30 Dec 2009 17:38:35 +0000

get a grip you sad fuck

By: marino

marino — Wed, 30 Dec 2009 15:09:26 +0000

Thank you baran lab – first time wet my pants while reading a paper.

synthesis of the decade…

By: GYA

GYA — Wed, 30 Dec 2009 12:46:43 +0000

palau’amine is out!

By: BS alert

BS alert — Tue, 29 Dec 2009 16:24:16 +0000

More BS from chinese: http://pubs.acs.org/doi/abs/10.1021/ja909038t

who wants to bet this is yet another case of oxygen doing an oxidation?

By: InfMP

InfMP — Fri, 25 Dec 2009 02:30:52 +0000

The mechanism proposed by Barton in the 1962 JCS is unlikely. Most people would not proposed the C=I+ intermediate.

The iodide adds to the diazonium and then base eliminates N2, securing the vinyl iodide.

By: stork naked

stork naked — Wed, 23 Dec 2009 17:03:37 +0000

i noticed that retraction as well… a bit overdue but the wheels of science grind away…