Comments on: Palau’amine http://totallysynthetic.com/blog/?p=2213 4,512 Ph. D. students died to make this blog... Thu, 09 Sep 2010 08:39:52 -0600 hourly 1 http://wordpress.org/?v=3.0 By: Orexigen, Contrave, And Obesity Firsts | The Haystack http://totallysynthetic.com/blog/?p=2213&cpage=2#comment-292721 Orexigen, Contrave, And Obesity Firsts | The Haystack Thu, 01 Apr 2010 14:53:24 +0000 http://totallysynthetic.com/blog/?p=2213#comment-292721 [...] group that specialized in total synthesis. While it’s true that I learned the value of being first to finish a molecule during those years, I also gained an appreciation for the fine syntheses that, [...] [...] group that specialized in total synthesis. While it’s true that I learned the value of being first to finish a molecule during those years, I also gained an appreciation for the fine syntheses that, [...]

]]> By: Ian http://totallysynthetic.com/blog/?p=2213&cpage=1#comment-279396 Ian Sat, 16 Jan 2010 10:29:05 +0000 http://totallysynthetic.com/blog/?p=2213#comment-279396 he throws books out promoting his work, when it is all pretty incremental, boring and has done nothing for our field He published an organocatalysis paper a while back, suggesting he is at least trying to contribute/improve methodology...nothing since though when he retires put someone in his job that is going to contribute he throws books out promoting his work, when it is all pretty incremental, boring and has done nothing for our field

He published an organocatalysis paper a while back, suggesting he is at least trying to contribute/improve methodology…nothing since though

when he retires put someone in his job that is going to contribute

]]> By: Ian http://totallysynthetic.com/blog/?p=2213&cpage=1#comment-279391 Ian Sat, 16 Jan 2010 09:16:12 +0000 http://totallysynthetic.com/blog/?p=2213#comment-279391 Exactly. Which is why KCN will never get anywhere near a Nobel. You need to change the subject, something he has not come close to doing and never will - as proven that he is trying to make maitotoxin. Jesus Christ what a waste of money. What Dave Evans has done for our subject makes him the stand out candidate in our field - you only have to compare the azaspiacid syntheses to see the enormous gulf in class between him and KCN Exactly. Which is why KCN will never get anywhere near a Nobel.

You need to change the subject, something he has not come close to doing and never will – as proven that he is trying to make maitotoxin. Jesus Christ what a waste of money.

What Dave Evans has done for our subject makes him the stand out candidate in our field – you only have to compare the azaspiacid syntheses to see the enormous gulf in class between him and KCN

]]> By: Alexander http://totallysynthetic.com/blog/?p=2213&cpage=1#comment-279302 Alexander Fri, 15 Jan 2010 23:19:10 +0000 http://totallysynthetic.com/blog/?p=2213#comment-279302 Actually, the second volume of "Classics" already contains 2 Baran syntheses (CP-molecules and okaramine N). The first was done in Nicolaou's group during Baran PhD studies, the second - in Corey's lab as a postdoc. Moreover, Nicolaou chose okaramine N synthesis as the central one in this volume. Actually, the second volume of “Classics” already contains 2 Baran syntheses (CP-molecules and okaramine N). The first was done in Nicolaou’s group during Baran PhD studies, the second – in Corey’s lab as a postdoc.
Moreover, Nicolaou chose okaramine N synthesis as the central one in this volume.

]]> By: » Blog Archive » Publications-Junichiro Yamaguchi-[Itami Organic Chemistry Laboratory, Nagoya University] http://totallysynthetic.com/blog/?p=2213&cpage=2#comment-279265 » Blog Archive » Publications-Junichiro Yamaguchi-[Itami Organic Chemistry Laboratory, Nagoya University] Fri, 15 Jan 2010 18:11:02 +0000 http://totallysynthetic.com/blog/?p=2213#comment-279265 [...] in Nature, C&EN, Health Candal.com, Chemistry World Blog(RSC), Tot. Syn. Dot Com, Chem-Station, C2W - [...] [...] in Nature, C&EN, Health Candal.com, Chemistry World Blog(RSC), Tot. Syn. Dot Com, Chem-Station, C2W – [...]

]]> By: Em http://totallysynthetic.com/blog/?p=2213&cpage=1#comment-279243 Em Fri, 15 Jan 2010 13:49:26 +0000 http://totallysynthetic.com/blog/?p=2213#comment-279243 This also made it to Wired.com http://www.wired.com/wiredscience/2010/01/palauamine-synthesized This also made it to Wired.com

http://www.wired.com/wiredscience/2010/01/palauamine-synthesized

]]> By: AIK http://totallysynthetic.com/blog/?p=2213&cpage=1#comment-278811 AIK Wed, 13 Jan 2010 17:35:40 +0000 http://totallysynthetic.com/blog/?p=2213#comment-278811 Spot on, agree with all your posts. I have a feeling that people behind CO2-capturing chemistry or general Green Chemistry could be candidates for Nobel Prizes this decade. There was an interesting paper last spring on a reaction where CO2 was turned into Methanol in a heterocyclic carbene catalyzed hydrosilane reduction sequence. That kind of chemistry will be the shit that will gain much attention. Spot on, agree with all your posts. I have a feeling that people behind CO2-capturing chemistry or general Green Chemistry could be candidates for Nobel Prizes this decade. There was an interesting paper last spring on a reaction where CO2 was turned into Methanol in a heterocyclic carbene catalyzed hydrosilane reduction sequence. That kind of chemistry will be the shit that will gain much attention.

]]> By: aaaa http://totallysynthetic.com/blog/?p=2213&cpage=1#comment-278499 aaaa Tue, 12 Jan 2010 20:04:08 +0000 http://totallysynthetic.com/blog/?p=2213#comment-278499 Well, usually, if three guys get the prize, at least one is the developer etc. But still, this sort of degrades the Nobel prize. The idea still is to award it to inventors or discoverers. One of the "best" winners was 1993 K. B. Mullis for the PCR invention. This is probably one of the best prizes in Chemistry in the last 20 years. He really invented the technique and it is used worldwide nowadays. This is the basic idea of the prize, unfortunately, there are not enough real discoveries nowadays in chemistry. Well, usually, if three guys get the prize, at least one is the developer etc. But still, this sort of degrades the Nobel prize. The idea still is to award it to inventors or discoverers. One of the “best” winners was 1993 K. B. Mullis for the PCR invention. This is probably one of the best prizes in Chemistry in the last 20 years. He really invented the technique and it is used worldwide nowadays. This is the basic idea of the prize, unfortunately, there are not enough real discoveries nowadays in chemistry.

]]> By: Hey hey now http://totallysynthetic.com/blog/?p=2213&cpage=1#comment-278455 Hey hey now Tue, 12 Jan 2010 15:12:09 +0000 http://totallysynthetic.com/blog/?p=2213#comment-278455 this is totally not true.... just look at a recent GFP and Dr. Tsien! He didn't invent it... he implemented it! this is totally not true…. just look at a recent GFP and Dr. Tsien! He didn’t invent it… he implemented it!

]]> By: aaaa http://totallysynthetic.com/blog/?p=2213&cpage=1#comment-278427 aaaa Tue, 12 Jan 2010 13:40:18 +0000 http://totallysynthetic.com/blog/?p=2213#comment-278427 Got to talk to a professor who is in the Nobel Committee. He told me that many were against that Corey got the prize, and he said many still think he should not have gotten one even today. Why? Because The Nobel prize is awarded for an Invention! You might publish a small paper with some brilliant idea in TL, your successor might develop this idea and publish 100 Angewandtes, still the man who deserves the prize is the one who Invented the thing. That is the major difference between an award and the Nobel prize. It does not matter how brilliant you are in the field - you must be the first one and an inventor, not just an implementer. According to him, it is absolutely unlikely that another guy gets the prize for just total synthesis. If he (Baran) is so good and hopes to get Nobel prize soon, he better shift his huge total-synth resources to methodology and reaction developement. Got to talk to a professor who is in the Nobel Committee. He told me that many were against that Corey got the prize, and he said many still think he should not have gotten one even today. Why? Because The Nobel prize is awarded for an Invention! You might publish a small paper with some brilliant idea in TL, your successor might develop this idea and publish 100 Angewandtes, still the man who deserves the prize is the one who Invented the thing. That is the major difference between an award and the Nobel prize. It does not matter how brilliant you are in the field – you must be the first one and an inventor, not just an implementer. According to him, it is absolutely unlikely that another guy gets the prize for just total synthesis. If he (Baran) is so good and hopes to get Nobel prize soon, he better shift his huge total-synth resources to methodology and reaction developement.

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