Comments on: Crambidine

By: Martyn

Martyn — Sun, 14 Mar 2010 13:53:42 +0000

It’s a CH2OTBS – the TBS comes off leaving an NCH2O- aminal anion, which loses formaldehyde to give the deprotected amine.

By: tntjdrn

tntjdrn — Sun, 14 Mar 2010 05:47:28 +0000

great synthesis!
but i dont know how they could deprotect CH2TBS group of the amine using fluoride. i think only TBS group can be deprotected.
plz tell me the mechanism.

By: lapetitechimiste

lapetitechimiste — Thu, 18 Feb 2010 10:38:54 +0000

Brilliant!

By: anon

anon — Fri, 05 Feb 2010 23:51:54 +0000

Sorry to burst your bubble but ‘is this correct or not’ should always be on your mind when you read any scientific work.

SI is there so you can draw your own conclusions about the statements in the paper.

By: Tok

Tok — Fri, 05 Feb 2010 21:45:43 +0000

It’s 20mb total, not per collection. So if you’re not johnny-on-the-spot with FTPing your data off the server regularly and backing it up somewhere safe, it can get deleted for good.

My point is that sloppy data backup techniques do not equal academic fraud.

By: _

Fri, 05 Feb 2010 19:45:38 +0000

Presenting your data in as clear, concise, and direct a manner as possible is a part of scientific conduct. The goal in reporting scientific findings is to ELIMINATE speculation.

The fact that we are even having this conversation means that there’s something wrong with the data. That doesn’t mean that it is fraud, but these questions should never be in your mind when pulling up ANY peer-reviewed SI.

By: Ian

Ian — Fri, 05 Feb 2010 17:27:32 +0000

Some of Corey’s spectra are probably still on hard disk somewhere there

Tippex is not a great idea

By: European Chemist

European Chemist — Fri, 05 Feb 2010 16:41:10 +0000

Ian has a point.

But, as it is apparent from this discussion, NONE OF US KNOWS EXACTLY WHAT HAPPENED. And so, claiming “scientific misconduct” or that “it’s humiliating for the whole synthetic society that we can only present such low quality material to Science” is really WAAAAY over the top. Until we know what really motivated that we can only speculate. Which apparently is what (some) Organic Chemists like most.

By: Ian

Ian — Fri, 05 Feb 2010 10:09:30 +0000

Why is anything erased from any spectra? If the spectra is not good enough run it again

If someone has drawn all over it grab the electronic file?

I refuse to believe that a university that hosts Scott Denmark and John Hartwig does not provide its students with the facility to save all spectra computationally.

By: Three Chemistry Sites for You « Loose Morels

Three Chemistry Sites for You « Loose Morels — Fri, 05 Feb 2010 06:55:18 +0000

[...] … but it’s interesting to see how the other half lives. Who couldn’t love: Crambidine though it seems to have gotten them a bit riled up. If nothing else, the sheer complexity reminds [...]