Comments on: F.A.Q. http://totallysynthetic.com/blog 4,512 Ph. D. students died to make this blog... Thu, 09 Sep 2010 08:39:52 -0600 hourly 1 http://wordpress.org/?v=3.0 By: Freuts http://totallysynthetic.com/blog/?page_id=287&cpage=1#comment-298817 Freuts Sun, 02 May 2010 18:22:45 +0000 http://totallysynthetic.com/blog/?page_id=287#comment-298817 Add to favorites, I'll use it. Add to favorites, I’ll use it.

]]> By: Michelle http://totallysynthetic.com/blog/?page_id=287&cpage=1#comment-296949 Michelle Sat, 24 Apr 2010 21:17:54 +0000 http://totallysynthetic.com/blog/?page_id=287#comment-296949 I'm an English professor at Auburn University in Alabama, and I'm writing a book about Science 2.0. My second chapter includes a case study of Totally Synthetic as an example of how blogs and other social networking sites are challenging traditional scientific publication practices. If you are willing, I'd like to ask you a few questions at your convenience. I’m an English professor at Auburn University in Alabama, and I’m writing a book about Science 2.0. My second chapter includes a case study of Totally Synthetic as an example of how blogs and other social networking sites are challenging traditional scientific publication practices.

If you are willing, I’d like to ask you a few questions at your convenience.

]]> By: Jobde http://totallysynthetic.com/blog/?page_id=287&cpage=1#comment-294341 Jobde Wed, 14 Apr 2010 16:35:12 +0000 http://totallysynthetic.com/blog/?page_id=287#comment-294341 Also agree with the author, all true. Also agree with the author, all true.

]]> By: suku http://totallysynthetic.com/blog/?page_id=287&cpage=1#comment-284145 suku Wed, 24 Feb 2010 23:11:08 +0000 http://totallysynthetic.com/blog/?page_id=287#comment-284145 i am new to this website i am new to this website

]]> By: suku http://totallysynthetic.com/blog/?page_id=287&cpage=1#comment-284144 suku Wed, 24 Feb 2010 23:08:57 +0000 http://totallysynthetic.com/blog/?page_id=287#comment-284144 do i need to register at this blog site. If so, how? i did not find any do i need to register at this blog site.
If so, how?
i did not find any

]]> By: Tim http://totallysynthetic.com/blog/?page_id=287&cpage=1#comment-283488 Tim Sat, 20 Feb 2010 11:39:21 +0000 http://totallysynthetic.com/blog/?page_id=287#comment-283488 Hi have subscribed for a year or so but last updating entry is 29 Dec and IE8 now has feed errors and cannot update. I remove and re-add your feed and it says RSS2 feed errors in code (text dump at bottom) can you fix as really love this blog. Cheers Tim PS if add it as "totallysynthetic.com/blog/?feed=rss" not rss2 (eg no pics) all is OK An invalid character was found in text content. Line: 248 Character: 709 Y’know, I was kinda hoping for a bit of break between blog-posts this winter, as the amount of online publications tends to tail-off around the year-end. However, not only have the publications been thick-’n'-fast (got quite a lot of material to get through), but up pops palau’amine. I really did think that Angewandte would hold-off until sometime in early 2010, but here it is – and it lives up to Baran’s reputation. I mean that in every sense, as in some ways there’s a slight dissapointment, as he has a way of making the synthesis look to obivious, too easy. However, it was undoubtedly a challenge; Baran states that ‘<em>the synthesis of palau’amine has thus far eluded organic chemists despite the dozens of Ph.D. theses… Many well-founded and logical plans to secure the peculiar </em>trans<em>-5,5 core <em>of </em>[palau'amine] <em>in our laboratory resulted in unfortunate outcomes</em>‘. This goes some-way to explaining the brevity of this blog post, but I intend to follow-up this post with a quick review of other routes that have been attempted in other labs.</em> Hi
have subscribed for a year or so but last updating entry is 29 Dec and IE8 now has feed errors and cannot update. I remove and re-add your feed and it says RSS2 feed errors in code (text dump at bottom) can you fix as really love this blog.
Cheers Tim
PS if add it as “totallysynthetic.com/blog/?feed=rss” not rss2 (eg no pics) all is OK

An invalid character was found in text content.
Line: 248 Character: 709

Y’know, I was kinda hoping for a bit of break between blog-posts this winter, as the amount of online publications tends to tail-off around the year-end. However, not only have the publications been thick-’n’-fast (got quite a lot of material to get through), but up pops palau’amine. I really did think that Angewandte would hold-off until sometime in early 2010, but here it is – and it lives up to Baran’s reputation. I mean that in every sense, as in some ways there’s a slight dissapointment, as he has a way of making the synthesis look to obivious, too easy. However, it was undoubtedly a challenge; Baran states that ‘the synthesis of palau’amine has thus far eluded organic chemists despite the dozens of Ph.D. theses… Many well-founded and logical plans to secure the peculiar trans-5,5 core of [palau'amine] in our laboratory resulted in unfortunate outcomes‘. This goes some-way to explaining the brevity of this blog post, but I intend to follow-up this post with a quick review of other routes that have been attempted in other labs.

]]> By: Peter Bladon http://totallysynthetic.com/blog/?page_id=287&cpage=1#comment-278869 Peter Bladon Thu, 14 Jan 2010 00:00:38 +0000 http://totallysynthetic.com/blog/?page_id=287#comment-278869 Hi I liked the reference to "golden age of steroid synthesis" in your piece about Cephalostatin 1. However, it is a pity that the reference used "et al" and so failed to mention Ivor Williams and William McMeekin who did the "heroic work" all those years ago. "Heroic" is perhaps a better adjective because in those days H$S did not rule. What is interesting about the original paper in JACS (in particular the supporting information) is the lack of any crystalline compounds. Cheers Peter Bladon Hi
I liked the reference to “golden age of steroid synthesis” in your piece about Cephalostatin 1. However, it is a pity that the reference used “et al” and so failed to mention Ivor Williams and William McMeekin who did the “heroic work” all those years ago. “Heroic” is perhaps a better adjective because in those days H$S did not rule.

What is interesting about the original paper in JACS (in particular the supporting information) is the lack of any crystalline compounds.

Cheers

Peter Bladon

]]> By: Efficient enantioselective transformation of lemons to lemonade: a reflection « Chiral Jones http://totallysynthetic.com/blog/?page_id=287&cpage=1#comment-275539 Efficient enantioselective transformation of lemons to lemonade: a reflection « Chiral Jones Fri, 25 Dec 2009 04:26:02 +0000 http://totallysynthetic.com/blog/?page_id=287#comment-275539 [...] Sorry the .gif looks a little grody. Even the tried and true Tot. Syn method produced weird lookin’ results… Just give it a click, I promise it looks [...] [...] Sorry the .gif looks a little grody. Even the tried and true Tot. Syn method produced weird lookin’ results… Just give it a click, I promise it looks [...]

]]> By: allan http://totallysynthetic.com/blog/?page_id=287&cpage=1#comment-274333 allan Sun, 13 Dec 2009 21:24:16 +0000 http://totallysynthetic.com/blog/?page_id=287#comment-274333 Hi Paul, Can i bother you with something? I would like to ask if you have come across with any methods of olefinating or methylenating C=O's of C-5 substituted gamma hydroxybutenolides (GHBs). I have browsed the literature and have found that GHBs are in equilibrium with its (open) 5-keto 1-carboxyl form. Is there any way to supress this like perhaps protecting the OH group with Me or Ac? Or there is a direct way to olefinate the carbonyl grp without adding such protective step? Maybe you have some tricky ideas? I would appreaciate it very much if you could help me. Thanks!!! Allan PS. the e-mail add indicated above does not work. my msg bounced back. Hi Paul,

Can i bother you with something? I would like to ask if you have come across with any methods of olefinating or methylenating C=O’s of C-5 substituted gamma hydroxybutenolides (GHBs). I have browsed the literature and have found that GHBs are in equilibrium with its (open) 5-keto 1-carboxyl form. Is there any way to supress this like perhaps protecting the OH group with Me or Ac? Or there is a direct way to olefinate the carbonyl grp without adding such protective step? Maybe you have some tricky ideas?

I would appreaciate it very much if you could help me. Thanks!!!

Allan

PS. the e-mail add indicated above does not work. my msg bounced back.

]]> By: Karl Collins http://totallysynthetic.com/blog/?page_id=287&cpage=1#comment-274298 Karl Collins Sun, 13 Dec 2009 15:20:34 +0000 http://totallysynthetic.com/blog/?page_id=287#comment-274298 Hi, This probably is not the right place to ask but I am stuck. I'm looking for 2nd year opportunities to present a poster and am struggling to find much. Does anybody know of any or a decent place to start looking? Thanks, Karl Hi,

This probably is not the right place to ask but I am stuck. I’m looking for 2nd year opportunities to present a poster and am struggling to find much. Does anybody know of any or a decent place to start looking?

Thanks,

Karl

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