Home » Archive

Articles Archive for November 2007

Still In The RBF »

[8 Nov 2007 | 50 Comments | 15,079 views]

Trost, Waser and Meyer, JACS, 2007, EarlyView. DOI: 10.1021/ja076165q.
I think this natural product can be considered different enough from the Amphidinolides that were the subject of the last synthesis, manifesting in some pretty exotic key steps. But let’s not get too far ahead of ourselves, as this isn’t a particularly well known beast. Antifungal, antifertility, cytotoxic and activity against multidrug resistant cancer cell lines sums up the biological activity in what appears to be a potent little target; appealing enough for lots of …

Still In The RBF »

[1 Nov 2007 | 14 Comments | 7,897 views]

Fürstner, Bouchez, Funel, Liepins, Porée, Gilmour, Beaufils, Laurich and Tamiya. ACIEE, 2007, EarlyView. DOI: 10.1002/anie.200704024.
Apologies for the lack of blogging – turns out this writing-the-thesis thing is quite time consuming. Feel free to talk amongst yourselves… Anyway, normal service has been resumed for today, with another Amphidinolide in the bag (actually a pair – Amphidinolide H & G). As with a lot of macrolide syntheses, there’s plenty of leg-work to get the fragments together, and a degree of familiarity due to the type of …