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Articles Archive for December 2008

Still In The RBF »

[15 Dec 2008 | 43 Comments | 13,476 views]

Kobayashi, Yamashita, Murata, Hikage, Takao, Nakazaki, and Kitahara. ACIEE, 2008, EarlyView. DOI: 10.1002/anie.200804544. , ACIEE, 2008, EarlyView. DOI: 10.1002/anie.200804546.
When the synthesis is spaced over two papers, you know it’s a biggie; a true beast of a natural product, Norzoanthamine made the gloried pages of Science when it was first completed by Miyashita back in 2004. Bulging with interesting biological activity (the headline being prevention of decrease in bone weight in osteoporotic mice), med-chem work is apparently under way. Coupled with a lack of comments about ‘scarcity’ …

Still In The RBF »

[4 Dec 2008 | 143 Comments | 99,237 views]

Trost and Dong. Nature, 2008, 456, 485. DOI: 10.1038/nature07543.
Ah, back in to Nature for another nibble at organic synthesis for the biologists, and some slightly-odd looking structures. It took me rather a while to get used to COOMe rather than CO2Me… However, one thing guaranteed with chemistry in Nature is quality, and it certainly shows in Trost’s latest work.
The target is one he’s been working on for quite a while, but with good reason, as it’s quite a tasty number. To quote the paper, they …