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Articles Archive for May 2009

Still In The RBF »

[29 May 2009 | 13 Comments | 8,223 views]
Arboricine

van Maarseveen, Hiemstra, Wanner, Boots, Eradus and de Gelder. Org. Lett., 2009, ASAP. DOI: 10.1021/ol900888e.
Okay, jsut a little Org. Lett. to get my hand back into this blogging thing after being on holiday for a week.  The writing conditions have changed a little in Tot Syn towers, too – I’m now typing this on a new keyboard – a lovely aluminium Apple thing.  So I bid my old Microsoft ‘Natural’ keyboard goodbye, after six years of faithful service, and also six years of crud (putting …

Still In The RBF »

[20 May 2009 | 22 Comments | 14,214 views]
5-epi-vibsanin E

Davies, Williams, Schwartz, Denton, Lian. JACS, 2009, ASAP. DOI: 10.1021/ja9019484.
Now that’s a substituted ring…  done and dusted by Huw Davies and Craig Williams as a collaborative effort (I’d quite like to know how this worked, as the two groups are quite removed), with Davies weighing in with some smart chemistry for building seven-membered rings.  This clearly critical to the synthesis of such a molecule, but the challenge is the heavy substitution, which has thwarted several groups (including individual efforts).  Whilst this paper doesn’t complete the …

Still In The RBF »

[17 May 2009 | 53 Comments | 20,250 views]
Eudesmane Terpenes

Baran, Chen. Nature, 2009, AOP. DOI: 10.1038/nature08043.
They say that the best defence is a good offence, so I’m going to start latterly – and remind (somewhat forcefully, if necessary) all prospective commenters that the folks at Nature decreed that this paper is worthy.  That’s good enough for me, so let’s avoid the tired arguments about suitability… </pre-emptive rant>
Anyway, what we’ve got here is typical of Baran – re-examination of chemical methodology of the past, and modernisation to solve problems in an orthogonal fashion.  Breaking that down, …

Meta »

[14 May 2009 | 11 Comments | 7,461 views]
Calling all Brits!

Fellow Brits!  Time to raise your heads from newspapers documenting the slow-motion car-crash that is Gordon Brown’s career, and petition the government!  Why?  Because the EPSRC are planning to change the process of applying for funding.
Apparently, they want to blacklist researchers who apply for funding but are unsuccessful in their application in more than 75% of cases.  Most academics get the odd proposal refused, so the average failure rate is 65-85% – meaning many would be black listed.  Please consider signing the petition (created by Prof. Joe Sweeny):
http://petitions.number10.gov.uk/UKScience/
This proposal …

Still In The RBF »

[10 May 2009 | 31 Comments | 12,551 views]
Amphidinolide X

Lee, Jung. ACIEE, 2009, EarlyView. DOI: 10.1002/anie.200900865.
Another month, another amphidinolide – but we’re getting pretty close to the end of the alphabet now.  Actually, I’m (as ever) being rather over-the-top – we’ve not actually covered that many, but X & Y (as well as being an affront to my ears) were blogged in 2006, where the focus was on the THF synthesis.  This is the case again with Eun Lee’s synthesis, which almost disregards the polyketide-style sections.
The key to his synthesis of the THF is a …

Still In The RBF »

[4 May 2009 | 58 Comments | 18,830 views]
Acutumine

Castle, Li, Tartakoff. JACS, 2009, ASAP. DOI: 10.1021/ja9024403.
First-time out for this complex little target – not big, but with five contiguous stereocenters, including a neopentylic chlorine and two quat-carb centers.  Enough to get busy with, then.  Biology-wise, Castle doen’t exactly wax-lyrical – he mentions selective T-cell cytotoxicty, and “antiamnesic-effects” (sounds good for a Saturday night-out), but that can’t have taken up much space in the grant application.
Let’s move on to the chemistry – stepping in at a rather advanced step in this Org. Lett., published in …