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Articles Archive for March 2010

Still In The RBF »

[28 Mar 2010 | 14 Comments | 17,143 views]
Actinophyllic Acid

Overman, Martin, Rohde. JACS, 2010, ASAP. DOI: 10.1021/ja100178u.
I don’t think there is a single academic whose syntheses I look forward to more than Larry Overman.  I’m not sure exactly why that it, but I think the main reason is the overall standard of his work, as well as his tendency to write fascinating and informing full-papers.  He’s also one of those professors who ‘owns’ a particular type of natural product; ‘Overman molecules’ are of course, alkaloids.
This paper not only discusses a ‘first synthesis’ in a racemic form, but also a …

Editorial »

[21 Mar 2010 | One Comment | 11,041 views]
First Disclosures @ SF ACS

Just a quick postlet to point everyone to Chemistry & Engineering News’ Live Blogging on medicinal chemistry at the San-Fran ACS.  Carmen Drahl will be giving details of clinical candidates, targets and activity information as they’re announced – a big deal to us Med Chemists.
She’s got a blog (or will have very shortly) called the Haystack.  Or you can follow it all on twitter, @carmendrahl .  You can follow me too, though I’m not at the ACS – I’m at a wedding in Selby.  But Selby is the SF of …

Still In The RBF »

[16 Mar 2010 | 13 Comments | 14,023 views]
Coralloidolides A, B, C, and E

Trauner, Kimbrough, Roethle, Mayer. ACIEE, 2010, EarlyView. DOI: 10.1002/anie.200906126.
It’s not often I get to summarise an entire paper in one scheme, so I’m not.  Erm, what I mean to say is that I could, but I think for decencies-sake, I’m going to pad this out a bit!  Back in 2006, Dirk Trauner (still at Berkeley back then) completed a rather neat synthesis of Bipinnatin, completing the target in a rather neat nine steps (including a very nice Alder-ene reaction…).  This synthesis was actually a means to …

Still In The RBF »

[3 Mar 2010 | 67 Comments | 23,372 views]
Echinopine A

Nicolaou, Chen, Ding, Richard. JACS, 2010, ASAP. DOI: 10.1021/ja9093988.
As I twittered the earlier today, redrawing KC’s crayonisation of Echinopine A took quite a while – but I think one needs to see both representations to get a feeling for the complexity here.  The unique [3.5.5.7] carbon skeleton is pretty special – apparently enough that no biological rationale is given for this work.  Perhaps I spend too much time looking a biological assay results these days…
So with nothing else for me to witter-on about, I’ll get into …