Articles Archive for March 2010
Still In The RBF »
Overman, Martin, Rohde. JACS, 2010, ASAP. DOI: 10.1021/ja100178u.
I don’t think there is a single academic whose syntheses I look forward to more than Larry Overman. I’m not sure exactly why that it, but I think the main reason is the overall standard of his work, as well as his tendency to write fascinating and informing full-papers. He’s also one of those professors who ‘owns’ a particular type of natural product; ‘Overman molecules’ are of course, alkaloids.
This paper not only discusses a ‘first synthesis’ in a racemic form, but also a …
Editorial »
Just a quick postlet to point everyone to Chemistry & Engineering News’ Live Blogging on medicinal chemistry at the San-Fran ACS. Carmen Drahl will be giving details of clinical candidates, targets and activity information as they’re announced – a big deal to us Med Chemists.
She’s got a blog (or will have very shortly) called the Haystack. Or you can follow it all on twitter, @carmendrahl . You can follow me too, though I’m not at the ACS – I’m at a wedding in Selby. But Selby is the SF of …
Still In The RBF »
Trauner, Kimbrough, Roethle, Mayer. ACIEE, 2010, EarlyView. DOI: 10.1002/anie.200906126.
It’s not often I get to summarise an entire paper in one scheme, so I’m not. Erm, what I mean to say is that I could, but I think for decencies-sake, I’m going to pad this out a bit! Back in 2006, Dirk Trauner (still at Berkeley back then) completed a rather neat synthesis of Bipinnatin, completing the target in a rather neat nine steps (including a very nice Alder-ene reaction…). This synthesis was actually a means to …
Still In The RBF »
Nicolaou, Chen, Ding, Richard. JACS, 2010, ASAP. DOI: 10.1021/ja9093988.
As I twittered the earlier today, redrawing KC’s crayonisation of Echinopine A took quite a while – but I think one needs to see both representations to get a feeling for the complexity here. The unique [3.5.5.7] carbon skeleton is pretty special – apparently enough that no biological rationale is given for this work. Perhaps I spend too much time looking a biological assay results these days…
So with nothing else for me to witter-on about, I’ll get into …