Bradshaw, Bonjoch, Etxebarria-Jard?´. JACS, 2010, ASAP. DOI: 10.1021/ja101994q.
It’s been a while since I wrote about a synthesis from Spain, so it’s nice to return with a rather sweet synthesis from the labs of Josep Bonjoch and his compatriot, Ben Bradshaw. Their efforts have been focused towards a sub-set of diterpenoids produced by Aspergillus, in which the decalin ring junction contains a pair of quaternary carbons.  That’s a pretty significant challenge by itself, but the rest of the decalin in subsituted in an all cis- arrangement, making for …

Apologies for the lack of blogging, friends.  This has in part been due to a lack of free time, but also to my computer going BANG.  A wisp of smoke and an horrendous smell indicate a ‘knackered’ power supply, so it’s going to be a little while longer before I’m back in action again. In the mean time, do read my CW article from last month – Polycavernoside A.  No surprises for guessing what next months CW piece will be – those intreguingly similar publications of Englerin A (one and …