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Still In The RBF »

[24 Jun 2010 | 29 Comments | 17,291 views]
Fastigiatine

Shair, Liau, JACS, 2010, ASAP DOI: 10.1021/ja104575h.
After wading through the Heathcock paper last week, I’m glad that today’s topic of discussion is a little shorter and easier to read.  (Seriously, part of me hates reading paper older that the 90′s as the style used in the schemes and figures is so difficult to follow.  Some of those 1960′s JACS papers are a real slog to get through – but worth it, normally….)
The target of choice today is Fastigiatine, a member of the Lycopodium alkaloid family, a popular …

Still In The RBF »

[17 Jun 2010 | 11 Comments | 12,310 views]
Fawcettimine

Jung, Chang, Org. Lett., 2010, ASAP DOI: 10.1021/ol1009762.
Although the number of actual steps in a formal synthesis is (or at least should be) smaller than in a full total-synthesis, I often feel that the actual work is harder.  Afterall, one is directly comparing ones work with that of another researcher, and in this case Michael Jung has got his work cut-out.  There aren’t many professors whose work is truly that daunting, but Clayton Heathcock is one of them. Jung’s work intercepts the Heathcock synthesis eight steps from then …

Still In The RBF »

[6 Jun 2010 | 42 Comments | 20,234 views]
Englerin A

Nicolaou, Chen, Kang, Ng, JACS, 2010, ASAP DOI: 10.1021/ja102927n.
Another popular target today; a last month I wrote a piece in Chemistry World about the first two syntheses of this target, and only a month later, up-pops Nicolau and Chen’s effort.  If nothing else, that’s a whole-lotta funding gone into this target, so it’s no surprise that it’s a pretty biologically active beastie. To quote KCN, ‘…potent and selective growth inhibitory (GI) activities against renal cancer cells‘ is the order of the day, so it’s worth all this effort. …