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Articles Archive for August 2010

Still In The RBF »

[29 Aug 2010 | 33 Comments | 25,799 views]
Solandelactone E

Aggarwal, Robinson. ACIEE, 2010, EarlyView. DOI: 10.1002/anie.201003236

A question – how long does one spin-out natural products based on one particular method?  I ask this as this is the second synthesis I’ve written about this year by Aggarwal, both using his lithiation–borylation–allylation sequence (the first one was in Chemistry World in June).  Aggarwal’s work is still very fresh – that’s why it’s on it’s second appearance here – but other groups have been stuck in a methodological rut for sometime (not wanting to name names here, but this is …

Still In The RBF »

[18 Aug 2010 | 17 Comments | 22,821 views]
Manzamine A

Fukuyama, Toma, Kita. JACS, 2010, ASAP. DOI: 10.1021/ja103721s
Ah – now this is a bit of a blast-from-the-past.  I knew I’d written something about this molecule before, so I had a quick rummage in the Tot. Syn. folder on my PC – and found nothing.  So I had a look in the other Tot. Syn folder, and another place I keep stuff for this website, and then four or five other places… (yeah, great filing system here) …and it turned up in this presentation I wrote a life-time ago.  You can …

Still In The RBF »

[7 Aug 2010 | 15 Comments | 20,248 views]
Cortistatins A (J, K and L) Pt. IV

Myers, Flyer, Si. Nat. Chem., 2010, AOP. DOI: 10.1038/nchem.794
Cortistatin is one of those targets like platensimycin that has attracted an almost unhealthy synthetic lust in the last few years, with three previous appearances in these interwebs (Baran, Nicolaou, Shair).  The reasons for both are the same – both have remarkable biological profiles, and both are of challenging complexity.  However, both are now what I’d call mature targets – in that the best disconnections have been tried, and that there are unavoidable methods that feature in most routes.  However, that …

Chemistry World, Still In The RBF »

[2 Aug 2010 | 9 Comments | 12,571 views]
Dictyosphaeric Acid A

This month’s Chemistry World piece is a rather nice synthesis of Dictyosphaeric Acid A by Richard Taylor’s group in York.