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Articles Archive for September 2011

Editorial »

[18 Sep 2011 | 32 Comments | 28,261 views]
An Egotistical Diatribe

One of the most impressive results of sharing thoughts on the internet the speed of insight – it doesn’t take long for two and two to bump together neatly. Last year, some bright sods noticed that I’d changed my by-line in my Chemistry World column. When once it said “Paul Docherty is a medicinal chemist based in London, UK”, it now reads “Paul Docherty is a science writer and blogger based in London, UK”. With my Facebook, Linked-In and Google+ accounts reflecting the change in more detail, it’s not surprising …

Still In The RBF »

[4 Sep 2011 | 64 Comments | 24,701 views]
Maoecrystal Z

Reisman, Cha, Yeoman. J. Am. Chem. Soc, 2011, ASAP. DOI: 10.1021/ja2073356 
A busy couple of weeks in the Reisman lab, it appears – really nice syntheses of the Cepharatines and 8-Demethoxyrunanine in Angewandte (doi: 10.1002/anie.201104487), but I decided to blog this tasty synthesis of Maoecrystal Z.  Of course, this isn’t the first member of that family that I’e blogged – the seminal synthesis of Maoecrystal V made my December 2010 column in Chemistry World.  I remember when I wrote that piece that the pseudo-3D structure used to represent the target annoyed …