Home » Archive

Articles Archive for December 2011

Featured, Still In The RBF »

[7 Dec 2011 | 23 Comments | 21,282 views]
Taxane Skeleton

Baran, Mendoza, Ishihara. Nature Chem., 2011, EarlyView. DOI: 10.1038/nchem.1196   
Hmm… I’m still not convinced about whether I should really post on this paper, but I’m interested in it, so to hell with the rules!  What we’ve got here is a sort-of meta-synthesis; Baran doesn’t actually make any of the taxane natural products, but demonstrates an extremely neat synthesis of a potential common precursor.  The theory behind the work is related to previous Baran diatribes, where he points out that too many steps in syntheses simply oxidise and reduce the same …