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Chemistry World: Callipeltoside A   

2 June 2008 8,188 views 16 Comments

As some of the more observant readers have already noticed, I’ve found myself a bit of ‘proper writing’ (it’s really weird to see my stream-of-conciousness in print!!!).  The folks at the RSC thought that little ‘ole Tot Syn was worthy of a monthly article in their Chemistry World publication, alongside Derek Lowe, Philip Ball and Dylan Stiles.  As I said in the comments, I’ll link to each article from here, but I won’t duplicate or rewrite that article, so you’ll have to make do for now!

The first one is on Evan’s synthesis of Callipeltoside A, and is in the June issue…

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  • Diego says:

    hey, Paul , congratulations.. but please keep this blog up to date, it´s really great news.

    Great job

  • Gryffin says:

    Excuse me, but in Figure 2. you misdrew a additional carbon on that aldehyde so it turned out to be a ketone. Nice job anyway and I always enjoy your work :-)

  • JareDTBMS says:

    Congrats Tot. Syn! I’m pleased to see you gaining some recognition in the wider synthetic organic chemical society :)

    I enjoy catching up here and trying to follow all the stimulating chemistry you lay before me. Thanks for taking the time to put all this work in – I’m sure your site could be likened to a modern day mini-Classics in Tot. Syn.

  • ZZZZZ says:


    …congrats on the new gig – I look forward to reading your views there; ok, back to sleep now…


  • icepoint says:

    Gryffin has sharp eyes!
    Anyway, congratulations on Tot. Syn.!

  • Tot. Syn. says:

    Gryffin, I noticed that too late… oh well! Typical for me to get a typo in the first article… Thanks for the kind words, folks!

  • milkshake says:

    congrats Chemistry World for having you!

  • the dude says:

    Hey Tot. Syn.,

    great that you are holding up the flag for total synthesis at chemistry world, but why did you chose an old Evans synthesis? The paper you cite is new, but the synthesis has been disclosed 2002 already. As a former Evans group member, I am of course delighted that people treasure his skill, but why not report on his newer syntheses like salvinorin a (I know you covered it in the blog)?


  • Heterogenius says:

    Thanks for the kudos on our synthesis (in my other life I am one of the authors on the paper)! Yah, yah… I know its an old synthesis. But at least we put some unpublished stuff in the full paper! The 1,5-induction stuff was a lot of work!

    And if “the dude” is Travis, I’m going to kick your butt at T&C’s wedding.



  • TheEdge says:

    I don’t think “the dude” is Travis. T-Bone would never use the word cheers, and he’d pick a Simpsons/Family Guy handle, not a Big Lebowski reference. FWIW, I’m pretty sure I know who it is, heterogenius, and I don’t think you overlapped with him.

    I liked the paper (and the write-up) even it should have been published years ago.

  • PG says:

    Congrats for your new column.

    I spotted a funny typo: Evans’ protégée David MacMillan.
    It should be protégé (no e at the end)… unless of course Dave McMillan has had a sex change.

  • milkshake says:

    I believe MacMillan has changed his hair color a bit since the time he was a postdoc – so who knows what else he/she…

  • dylan says:

    fricking fabulous! welcome to the party (this is dylan aka tenderbutton).

    my one and only one critism of the publication, probably no concern to you, is that the editing process entails “britifcation” of my writing. It’s alumiNUM not NIUM, i say.

  • jack says:

    From Wikipedia: The International Union of Pure and Applied Chemistry (IUPAC) adopted aluminium as the standard international name for the element in 1990, but three years later recognized aluminum as an acceptable variant. Hence their periodic table includes both, but places aluminium first.[31] IUPAC officially prefers the use of aluminium in its internal publications, although several IUPAC publications use the spelling aluminum.

  • Tot. Syn. says:

    Dylan – it’s not frickin’ sodnum, lithnum, or barum…! Seriously, don’t get me started on the Americanisation (with an ‘s’) of English…
    However, it’s great to join the blogging pioneers at CW!

  • Ugly American says:

    Even after many years, the pronunciation of words such as ethyl and methyl in British English still sounds strange to me, but aluminium takes the cake for me.

    My favorite language-based chemical differentiation is the German Jod and seeing its symbol J in international publications.

    Typically Americans are probably most baffled by the ubiquitous “zed” as the pronunciation of the letter Z by all of the other native speakers of “English”.

    As an American I am constantly amazed at Americans’ own dialects. If you get a room full of Americans, ask them what they call their soft drinks. While this probably pales in comparison to Great Britain’s regional dialects, you will get soda, soda pop, pop, and even coke (as in give me one of those Pepsi cokes please)