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Chemistry World: A Chlorosulfolipid   

5 March 2009 11,243 views 12 Comments


Latest piece for the RSC in the March issue of Chemistry World

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  • Great Expectations says:

    Brevetoxin not brevitoxin I’m afraid :D

  • Liquidcarbon says:

    What’s with the different colors and hazy shadows?

  • TWYI says:

    I thought that was just my eyes!

    Why is there fog around the schemes/conditions?

    • Tot. Syn. says:

      Ain’t got nuthin to do wiv me, boss… I just hands them a Word file and a few chemdraws.

      • Liquidcarbon says:

        I actually find it disturbing. An increasing amount of recent publications have very low-quality pictures. People may not know image processing, in this case it’s the editors’ job to point that out. TIFF, not PNG for print!!!

        • Tot. Syn. says:

          I think you’re right on several levels – it seems that the UK press are quite happy to use crappy camera-phone pictures in their broadsheets, even when they’re so blurred to be useless. The same seems to happen on TV, with pointless Youtube-quality videos shown on supposed hi-def stations. Argh. Fairly soon a picture will be worth about 14 words…

  • Madforit says:

    Hi guys,does anybody know if the in situ prepared LDA (Buli and DiPA in THF at 0 c) is red?Cheers

    • matt says:

      No it is not,it is colorless. But when you keep it at 0 C for some time, it starts to develop yellow tint.

  • Madforit says:

    Thank you so much matt…

  • TWYI says:

    Red LDA?

    • Tot. Syn. says:

      I always hated working with LDA… Distill with diisopropylamine, store over some drying agent, titrate the BuLi, and then re-titrate the LDA? And then chuck the whole lot after only a couple of weeks?! Nah, I always stuck to LiHMDS.
      However, apparently one can buy LDA in a bottle – but surely it’s only good for cleaning ovens, and unblocking drains…
      My strong base of choice was always sodium hydride – sure, washing the mineral oil off was a pest, but dumping the excess in the sink was an exciting bonus!

  • InfMP says:

    I’m really confused by that epoxide opening. You said that they accidentally got the syn product, but you drew the anti.

    So…a normal epoxide attack gives anti right? coming from the back.
    and then that means that their unintended double inversion would give the correct syn configuration.

    Am I just not seeing this in 3d?