12 Comments

• Great Expectations says:

  5 March, 2009 at 22:19

  Brevetoxin not brevitoxin I’m afraid
• Liquidcarbon says:

  6 March, 2009 at 8:56

  What’s with the different colors and hazy shadows?
• TWYI says:

  6 March, 2009 at 9:05

  I thought that was just my eyes!

  Why is there fog around the schemes/conditions?
  • Tot. Syn. says:

    6 March, 2009 at 10:53

    Ain’t got nuthin to do wiv me, boss… I just hands them a Word file and a few chemdraws.
    • Liquidcarbon says:

      9 March, 2009 at 22:11

      I actually find it disturbing. An increasing amount of recent publications have very low-quality pictures. People may not know image processing, in this case it’s the editors’ job to point that out. TIFF, not PNG for print!!!
      • Tot. Syn. says:

        9 March, 2009 at 23:47

        I think you’re right on several levels – it seems that the UK press are quite happy to use crappy camera-phone pictures in their broadsheets, even when they’re so blurred to be useless. The same seems to happen on TV, with pointless Youtube-quality videos shown on supposed hi-def stations. Argh. Fairly soon a picture will be worth about 14 words…
• Madforit says:

  6 March, 2009 at 18:24

  Hi guys,does anybody know if the in situ prepared LDA (Buli and DiPA in THF at 0 c) is red?Cheers
  • matt says:

    6 March, 2009 at 20:19

    No it is not,it is colorless. But when you keep it at 0 C for some time, it starts to develop yellow tint.
• Madforit says:

  6 March, 2009 at 20:22

  Thank you so much matt…
• TWYI says:

  7 March, 2009 at 3:11

  Red LDA?
  • Tot. Syn. says:

    8 March, 2009 at 13:51

    I always hated working with LDA… Distill with diisopropylamine, store over some drying agent, titrate the BuLi, and then re-titrate the LDA? And then chuck the whole lot after only a couple of weeks?! Nah, I always stuck to LiHMDS.
    However, apparently one can buy LDA in a bottle – but surely it’s only good for cleaning ovens, and unblocking drains…
    My strong base of choice was always sodium hydride – sure, washing the mineral oil off was a pest, but dumping the excess in the sink was an exciting bonus!
• InfMP says:

  14 March, 2009 at 17:19

  I’m really confused by that epoxide opening. You said that they accidentally got the syn product, but you drew the anti.

  So…a normal epoxide attack gives anti right? coming from the back.
  and then that means that their unintended double inversion would give the correct syn configuration.

  Am I just not seeing this in 3d?

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