Small Molecule Natural Products in the Discovery of Therapeutic Agents
Danishefsky and Wilson. JOC - Perspective, 2006, ASAP. DOI: 10.1021/jo0610053 .
An excellent review of a great topic – development of pharmaceutical agents derived from natural products. The paper covers a broad range of substrates, but particular focus is paid to Lipitor, Paclitaxel, prostaglandins and the epothilones. If you don’t look at anything else in this paper, check out page B, Scheme 1…
Additional: As mentioned by an astute commentator, the same authors have published a related artical in Acc. Chem. Res., DOI: 10.1021/ar068018n