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Nakadomarin A   

10 December 2009 9,287 views 4 Comments

rsc-dec

Yeah, I’ve not posted in a bit… Cephalostatin 1 is going into Chemistry World next month, but this months is also worth a read.  Darren Dixon’s synthesis of Nakadomarin A contains quite a few interesting transformation, and is very succinct.

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4 Comments

  • Gui says:
    10 December, 2009 at 19:59

    Question, I don`t understand how DAST can make oxazolines from beta hydroxyamides!! Please anyone help!!!!!! Does DAST fluorinate the primary alcohol or does it react as an intermediate???

    URGENT!!!!! THANK U!!!!
    (From Org. Lett., 2000, Vol 2, No8, 1165-1168)

  • me says:
    10 December, 2009 at 21:41

    I think it just acts as a dehydrating agent.

  • Billy says:
    14 December, 2009 at 14:44

    Now sorry guys, but is it just me who thinks that a reaction which heads over into the second week, uses 15% of a complex catalyst and only gives you 60% yield, 80-ish % DR is nothing to write home about…

  • Johnny says:
    15 December, 2009 at 6:33

    It’s not that bad when you make loads of the starting materials.