Macrocyclization by Ring-Closing Metathesis in the Total Synthesis of Natural Products: Reaction Conditions and Limitations
PÃ©rez-Castells and Gradillas. ACIEE, 2006, Early View. DOI: 10.1002/anie.2006006410.
This review article covers the ever-popular RCM step in natural product synthesis. The range of architectures is impressive, as you might expect, as is the range of ring-sizes. However, a certain theme develops as this paper contains 24, count them, reference to Alois FÃ¼rstner’s work.
However, the scope of the article is good, detailing the conditions used in each synthesis, and those condition which failed. RCM (and metathesis in general) is a relatively new field, and we as organic chemists are still getting to grips with the power of this reaction, but this paper makes for a great reference/tool kit.