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Conophylline   

5 June 2011 10,232 views 5 Comments

Fukuyama, Tokuyama, Han-ya. ACIEE, 2011, 50, 4884. DOI: 10.1002/anie.201100981 Article PDF Supporting Information Group Website

Not a full post, but it’s time to get some of these Chemistry World articles on here.  This once is the most recent, in the June issue, and follows Tohru Fukuyama’s synthesis on Conophylline – a really neat piece of work, especially when you consider how sensitive some of the functionality here is.  How many of you knew of the Polonovski-Potier reaction?

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5 Comments

  • James says:

    I think bis-indole alkaloids are the last untapped frontier of total synthesis. There’s a ton of beautiful structures out there that haven’t been made yet. This is a great example. Thanks for sharing Paul.

  • nicho says:

    Awsome synthesis, yet another notch under Fukuyama’s belt! Great work by a very hard working Japanese team.

  • Gilgerto says:

    Nice to ear back from you!

  • See Arr Oh says:

    Oooh! Pick me! I know EXACTLY what the Potier-Polonovski is! Oxidative degradation of alkyl chains between indole and basic nitrogens….I happened across it in a recent paper.

  • rhodium says:

    Truly enjoyable. So much of organic chemistry is just increasingly fancy nucleophiles reacting with increasingly fancy electrophiles. And thanks too to Fukuyama for putting his group’s mechanism problem sessions (with possible answers) on the web.