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Cascade Reactions in Total Synthesis   

30 October 2006 7,622 views 11 Comments


Nicolaou, Edmonds and Bulger. ACIEE, 2006, Early View. DOI: 10.1002/anie.200601872.

Another fantastic review in Angewantde this week from the team (or at least most of the team) that brought you Palladium Catalysis in Total Synthesis and Metathesis in Total Synthesis… this is building towards quite a bible! Not quite “Classics… III”, but still indispensable reading.

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  • Anon says:

    Don’t forget to gush about the “selenium in natural products synthesis”. That one just flew off the bookshelves.

  • TWYI says:

    Nice mention Of Harrans dz synthesis (the correct structure). The oxidative cyclisation of the tyrosine derivative is more than likely how nature constructs the quaternary centre. It’s just a shame about the formation of the unwanted diastereomer and that strange spiro compound.

  • Ochemist says:

    Hey Tot.Syn.,
    isn’t it time for the best october Total Synthesis poll?

  • Tot. Syn. says:

    Hey, it’s still October (in Cambridge, at least)!! I’ll put it up for the weekend – let things digest a little (thought the latter half of this month has been a bit slow…). You never know, there could have been something in the press today…

  • regularchem says:

    Talking about Selenium, Larocked work on organomercury chemistry at the beginning of his career. Once I heard a seminar by a guy (I forgot his name) about Te. It was intersting and he claimed that Te was not that toxic. Anyone knows someone working on Tl?

  • Anon says:

    No, but it gives you really bad breath. One of the more unusual periodic trends “bad smell down group 16″ It would be unbearable, but, luckily, it’s solid and not that volatile.

  • TWYI says:

    Tellurium may be Carl Scheisser (he is at Melbourne).

  • Tot. Syn. says:

    I had the privilege to see a talk by Eric Block on Monday, who quite frequently uses KSeCN and KTeCN… which, apparently, aren’t that nasty…

  • jimbo says:

    And I’ve seen talks by people saying that Ni(COD)2 is stable and easy to work with… :) Which is true, I guess, if you’re used to working in a glove box.

    It’s possible that those salts might not be that bad though. I used NaSMe once, which is quite a bit less terrible to work with than several liquid thiols I’ve used.

  • Jose says:

    The big name in Se and Te is in Brazil- João V. Comasseto.

  • Bad breath or halitosis can be easily elimated by using mouthwash with hexetidine or triclosan.`*”