Modern Aldol Methods for the Total Synthesis of Polyketides
Schetter and Mahrwald. ACIE, 2006, 45(45), 7506-7525; DOI: 10.1002/anie.200602780.
With all this focus on polyketide/macrolide synthesis, I thought I’d highlight an interesting review in this week’s Angewandte; a genuine masterclass in the aldol reaction. They highlight Woodward’s synthesis of erythromycin, an amazing read, just to see how far we’ve come. Also, the figure on page 7507 is incredible; showing the aldol disconnections used in other all of the syntheses of erythromycin so far.