Crimmins, and Slade. Org. Lett., 2006, ASAP. DOI: 10.1021/ol0607241
Formal synthesis of 6-Deoxyerythronolide B, using Crimmins aldol methodology (this blog’s turning into Aldol News) to put in eight of the nine stereocentres. Their method revolves around the iterative asymmetric acyl-thiazolidinethione propionate aldol:
Getting around 80% yield and >20:1 dr in each of these aldols makes this a pretty sweet job, if a little repetitive.