Trost and Dong. JACS., 2006, ASAP. DOI: 10.1021/ja061105q
A very rapid synthesis of Agelastatin A, using palladium chemistry (surpise) in two steps. However, both these steps go in remarkable yield, completing the 5-6-5 core of the target in four steps!
The remaining 5-member ring is constucted in an elegant two-step process; aziridination using a new-to-application N-heterocyclic carbene catalyst, followed by hydrolytic ring opening. Top stuff.