Feng, Tian, Yuan, Mu and He. Org. Lett., 2007, 9, 2019. DOI: 10.1021/ol070597o.
Bear with me on this one – I guess you’ve seen this target before. I was shown this paper by a few of the chaps in our group, and was just astounded with the transformation, and even more by the mechanism.
Awesome! But the mechanism contains some rather worrying steps. I’ve capture the entire thing directly from the supp. info., cause even I can’t be bothered redrawing that:
(The supp. info., BTW, is here.)
I’m particularly concerned by the Fe-mediated addition of carbon dioxide to formaldehyde. Any thoughts?