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Maitotoxin   

7 May 2007 34,181 views 77 Comments

maitotoxin.jpg

Nicolaou. ACIEE, 2006, Early View. DOI: 10.1002/anie.200604656.

Nope, it’s not done yet (slackers…), but there’s a very interesting KCN penned piece in Angewandte this week as an essay on the structure of Maitotoxin. It’s certainly been an intimidating challenge for the synthetic community for sometime, but with a molecular weight of 3422 g-1mol, LD50 of 50ng (yes, nanograms… I read a paper that states “a gram of maitotoxin can kill
approximately half a billion mice”), and nearly 100 stereocentres, it’s going to take some doing. Interestingly, there may be a flaw in the original Kishi assignment of stereochemistry, and it’s the Rychnovsky method to the rescue again… using 13C NMR prediction to determine structure. What follows is an stimulating discussion.

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77 Comments

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  • [...] that’ hasn’t stopped people from messing around with it. And there’s much speculation that other people are strongly considering messing around with it, too – you synthetic chemists can [...]

  • Crofewer says:

    Active molecule can be very very short.You do not need complete synthesis.But this is powerfull weapon very similar to nuke.
    Nobody can survive on hit region.

  • Crofewer says:

    Now price is 10 million Euro.Antidote is not included,but I know tham.

  • Crofewer says:

    Final solution is Palytoxin anolog(real God).
    This anolog can kill God himself(autodestruction).
    Problem is that people do not know who is God.
    I know.Nation and God is problem some people believe.
    Language is not problem.You perfect understand a problem.

  • Crofewer says:

    Fact no.1:
    Light-weight maitotoxin anolog can kill approximately 1 million peple(travel on air).
    Fact no 2:
    One light-weight palytoxin anolog can kill God and people.Total destruction(useless).
    Fact no.3:
    Second light-weight palytoxin anolog can kill only people.God will survive.This is for armageddon.
    Watch your language Mr.promprog.You must obey to real God.Do not disturb them.You are probably a politician.Your contry never have this anologs.Now you are enemy(public).Thank You teadrinkers.

  • Crofewer says:

    I forget too say,only 1kg of that anolog can cause that effects(maitotoxin).I give to North Corea that anologs for free.Can you imagine that?

  • Crofewer says:

    All three anologs are lipid soluble liqid.They evaporate very easy to atmosphere.Moisture in air interact with maitotoxon anolog and became toxic.Molecules are very stable and when wind blow they destroy everything on his way.One molecule of maitotoxin anolog can kill a man.Only this anolog is for sale.

  • Crofewer says:

    Dinero,per favore senor and i give to you a terrible weapon.
    This is only a business.

  • Crofewer says:

    Maybe you want buy Palytoxin anolog but they will eat your heart for breakfast.

  • Crofewer says:

    Somethig terrible is in the air.

  • Crofewer says:

    If I publish,this civilization will vanish(dinosaur syndrome).
    If I sell,it is the same thing.The beast is still on a short chain.

  • Guenter Bedessem says:

    “Chemical synthesis always has some element of planning in it. But, the planning should never be too rigid. Because, in fact, the specific objective which the synthetic chemist uses as the excuse for his activity is often not of special importance in the general sense; rather, the important things are those that he finds out in the course of attempting to reach his objective”
    Robert Burns Woodward (1917-1979)

  • Crofewer says:

    My maitotoxin is sophisticated giant club(pure dead)designed to sock nuclear installations.It is nuclear antipode.We can make hell on Earth with one maitotoxin and one palytoxin anolog.But there is catch 22.We
    can make paradise on planet with one palytoxin anolog.This is material
    God,because that anolog can give life to dead matter.This anolog will
    destroy old Gods and saints.It will be only one saint,me,because I know exact formula.I’am not sure that people want paradise on Earth.
    Nobody can excel this knowledge.

  • Crofewer says:

    This is so sad.Think about this matter.

  • Crofewer says:

    My intention is to give life to dead DNA from dead people with one palytoxin anolog.It is possible.Formula is C18 H34 O3.This is my publication official.
    Leonard Opancar
    OPG Opancar Leonard
    Istraživanje i razvoj
    Address: SAG, B.Radica 62, 31550 Valpovo,Croatia
    Tel:+38531625979
    E-mail:leonard777@vip.hr
    OIB: 21906870978

  • Crofewer says:

    I can publish structural fofmula but i dont know how.

  • Crofewer says:

    slackers no no it is more than that.