Home » Archive

Articles tagged with: Johnson-Claisen

Still In The RBF »

[3 Mar 2010 | 67 Comments | 23,600 views]
Echinopine A

Nicolaou, Chen, Ding, Richard. JACS, 2010, ASAP. DOI: 10.1021/ja9093988.
As I twittered the earlier today, redrawing KC’s crayonisation of Echinopine A took quite a while – but I think one needs to see both representations to get a feeling for the complexity here.  The unique [] carbon skeleton is pretty special – apparently enough that no biological rationale is given for this work.  Perhaps I spend too much time looking a biological assay results these days…
So with nothing else for me to witter-on about, I’ll get into …

Still In The RBF »

[13 Jun 2009 | 56 Comments | 16,278 views]
Napyradiomycin A1

Snyder, Tang, Gupta. JACS, 2009, 131, 5744. DOI: 10.1021/ja9014716.
Okay, it’s taken me far too long to get around to this article – I actually wrote the Chemdraw back when this article was in ASAP… but other stuff got in the way, like a little Nature paper from Baran.  However, it’s a damned nice paper, so it’s impossible for me not to go back and look at it properly.  The target here is an halogenated natural product, isolated from Streptomyces bacteria – so it’s not too surprising …

Still In The RBF »

[30 Mar 2009 | 11 Comments | 11,194 views]

Qin, Zhang, Huang, Shen.JACS, 2009, ASAP. DOI: 10.1021/ja901219v.
It’s really nice to move on to a full paper this week after last weeks (lack of) communication nightmare, as it gives Yong Qin plenty of space to discuss his strategy for the synthesis of vincorine, including the missteps.  The target has seen quite a bit of action, having been completed by Vollhardt, Overman and Levy in the past, but Qin’s got quite a background in this family too.  In-case you’re sitting there thinking ‘I’ve seen this somewhere before…’, I’ll take …